Ofatumumab
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Ofatumumab Definition
A fully human, high-affinity IgG1 monoclonal antibody directed against the B cell CD20 cell surface antigen with potential antineoplastic activity. Ofatumumab binds specifically to CD20 on the surfaces of B cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) B cells overexpressing CD20. The CD20 antigen, found on over 90% of B cells of B cell lymphomas and other B cells of lymphoid tumors of B cell origin, is a non-glycosylated cell surface phosphoprotein that acts a calcium ion channel; it is exclusively expressed on B cells during most stages of B cell development.
Ofatumumab Synonyms
Ofatumumab, GSK1841157, HuMax-CD20, HuMax-CD20, 2F2, OFATUMUMAB
Terms in Ofatumumab category
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