PARP Inhibitor AZD2281
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PARP Inhibitor AZD2281 Definition
A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. PARP inhibitor AZD2281 selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.
PARP Inhibitor AZD2281 Synonyms
Olaparib, AZD2281, KU-0059436, PARP Inhibitor AZD2281
Terms in PARP Inhibitor AZD2281 category
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