PI3K-delta Inhibitor CAL-101
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PI3K-delta Inhibitor CAL-101 Definition
A small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.
PI3K-delta Inhibitor CAL-101 Synonyms
PI3K-delta Inhibitor CAL-101, CAL-101, Phosphoinositide-3 Kinase Delta Inhibitor CAL-101
Terms in PI3K-delta Inhibitor CAL-101 category
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