PLX4032
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Antineoplastic Agent ->
Signal Transduction Inhibitor -> PLX4032
PLX4032 Definition
An orally active B-RAF kinase inhibitor with potential antineoplastic activity. PLX4032 selectively targets and inhibits the B-RAF V600E protein, the most frequent mutant allele of B-RAF mutations associated with many cancers, especially malignant melanomas. Substitution of a valine with a negatively charged glutamic acid converts B-RAF into a constitutively active kinase, which accounts for increased tumor aggressiveness and decreased tumor survival in many types of cancers. Therefore, inhibition of V600E B-RAF may lead to a reduction in tumor growth.
PLX4032 Synonyms
B-Raf Inhibitor PLX4032, PLX4032
Terms in PLX4032 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.