PLZF-RARalpha
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Fusion Protein -> PLZF-RARalpha
PLZF-RARalpha Definition
Translocation t(11;17)(q23;21) fuses the PLZF gene on 11q23.1 to the RARA gene on chromosome 17 producing a 'dominant-negative' PLZF-RARA fusion protein in myeloid cells and resulting in APL. The oncogenic retinoic acid receptor mediates leukemogenesis through aberrant chromatin acetylation. Through the RAR-alpha CoR box, PLZF-RAR-alpha fusion proteins recruit the NCOR/histone deacetylase complex. (from OMIM 176797 and NCI)
PLZF-RARalpha Synonyms
PLZF-RARalpha, PLZF-RARA Chimera, Promyelocytic Leukemia Zinc Finger Protein/Retinoic Acid Receptor Alpha Chimera, ZNF145/RARA Chimera
Terms in PLZF-RARalpha category
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