PTEN Tyrosine Phosphatase
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PTEN Tyrosine Phosphatase Definition
PTEN contains a tyrosine phosphatase domain and a region of homology to auxilin and tensin (which interacts with actin). PTEN inhibits insulin-induced IRS1 phosphorylation and IRS1/GRB2/SOS complex formation and influences the PI3 kinase/AKT pathway in FAS-induced apoptosis. PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to cyclin-dependent kinase inhibitor p27(KIP1), increasing p27, decreasing cyclin D1, and inhibiting AKT phosphorylation. PTEN may regulate cell interactions with the extracellular matrix and effect cell migration, integrin-mediated cell spreading, and formation of focal adhesions. PTEN reduces tyrosine phosphorylation of FAK. The PTEN gene is transactivated by p53. (from OMIM 601728 and NCI)
PTEN Tyrosine Phosphatase Synonyms
PTEN Tyrosine Phosphatase, Mutated in Multiple Advanced Cancers 1, PTEN
Terms in PTEN Tyrosine Phosphatase category
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