Peldesine
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Purine Nucleoside Phosphorylase Inhibitor -> Peldesine
Peldesine Definition
A pyrimidine analogue and purine nucleoside phosphorylase inhibitor with immunosuppressive and antineoplastic properties. Peldesine inhibits purine nucleoside phosphorylase (PNP) that plays a pivotal role in T-cell proliferation and is responsible for the catalysis of the reversible phosphorolytic cleavage of purine ribonucleosides and 2'-deoxyribonucleosides.. Inhibition of PNP results in accumulation of dGTP and the subsequent failure to DNA synthesis. This agent maybe used in T-cell related autoimmune diseases including psoriasis, rheumatoid arthritis and Crohn s disease and T-cell cancers
Peldesine Synonyms
Peldesine, 4H-Pyrrolo(3,2-d)pyrimidin-4-one,1,5-dihydro-2-amino-7-(3-pyridinylmethyl), 9-(3-Pyridinylmethyl)-7H-9-deazaguanine, BCX-34, Peldesina, peldesine
Terms in Peldesine category
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