Plasminogen
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Plasminogen Definition
Plasminogen is a precursor of the potent serine protease plasmin and occurs at high concentrations in body fluids. Activation of plasminogen to the enzymatically active form plasmin is a proteolytic event and tightly controlled. A key feature in the formation and stability of plasmin activity is the attachment of plasminogen (and also of the formed plasmin) onto lysine-containing residues on target protein, such as fibrin. Plasmin cleaves fibrin clots and e.g. non-collagenous proteins of basement membranes and extracellular matrices, such as laminin and fibronectin. Plasmin also activates latent pro-collagenases and is thought to be crucial for the penetration of metastatic tumor cells into basement membranes.
Plasminogen Synonyms
Plasminogen, EC 3.4.21.7, PLG, PLMN
Terms in Plasminogen category
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