Polo-like Kinase 1 Inhibitor BI 6727
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Polo-like Kinase 1 Inhibitor BI 6727 Definition
A dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor BI 6727 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.
Polo-like Kinase 1 Inhibitor BI 6727 Synonyms
Polo-like Kinase 1 Inhibitor BI 6727, BI 6727, PLK-1 inhibitor BI 6727
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