Poly ADP ribose Polymerase
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Poly ADP ribose Polymerase Definition
The human protein poly(ADP ribose) polymerase protein (1013aa, ~113 kDa) is encoded by the PARP1 gene (PARP1). Poly(ADP ribose) polymerase (PARP) is a cytosolic protein, and when activated is cleaved into two fragments of 89kd and 24kd. The enzyme modifies various nuclear proteins by poly ADP-ribosylation. The protein is involved in the regulation of various important cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage. Its inhibition has been studied in cancerous cells and degenerative diseases to demonstrate how apoptosis can be inhibited when the PARP is inactive or absent.
Poly ADP ribose Polymerase Synonyms
Poly(ADP Ribose) Polymerase, PARP, PARP-1
Terms in Poly ADP ribose Polymerase category
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