Presynaptic Protein-SAP97
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Presynaptic Protein-SAP97 Definition
Encoded by human DLG1 Gene (MAGUK Family), alternative isoforms 1 (904-aa) and 2 (926-aa) of 100-kD Presynaptic Protein SAP97 are a putative kinase that appears to regulate protein targeting and contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. DLG1 binds to membrane cytoskeletal protein 4.1 (EPB41) and to KIF13B, and interacts with the KCNAB1 channel as well as the cytoplasmic tail of NMDA receptor subunits. LCK interacts with the proline-rich N-terminal domain of DLG1. Interacting with actin-binding ezrin, SAP97 is also involved in cell shape morphogenesis. (NCI)
Presynaptic Protein-SAP97 Synonyms
Presynaptic Protein SAP97, Discs Large (Drosophila) Homolog 1, Discs Large Homolog 1, Synapse-Associated Protein 97, hDlg
Terms in Presynaptic Protein-SAP97 category
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