Protein Geranylgeranyltransferase Type-I Beta Subunit

Cancer Terms -> Gene Product -> Protein -> Protein Complex Subunit -> Protein Geranylgeranyltransferase Type-I Beta Subunit

Protein Geranylgeranyltransferase Type-I Beta Subunit Definition

Encoded by human PGGT1B Gene (Protein Prenyltransferase Beta Subunit Family), 377-aa 42-kDa Protein Geranylgeranyltransferase Type I Beta Subunit is part of the alpha-beta heterodimeric GGTase-I, an enzyme that transfers a geranylgeranyl moiety to the Cys of a C-terminal CAAX motif in candidate proteins as a means of membrane localization. The 48-kDa alpha subunit of GGTase-I is identical to the alpha subunit (FNTA) of Farnesyl Protein Transferase. Containing 4 PFTB repeats, the beta chain (PGGT1B) of GGTase-I is distinct from the beta subunit (FNTB) of Farnesyl Protein Transferase; FNTB and PGGT1B are catalytic for specific substrates. The mammalian counterpart of CDC43 (S. cerevisiae) and responsible for peptide binding, PGGT1B acts on Rac1, Rac2, Rap1A, and Rap1B. (NCI)

Protein Geranylgeranyltransferase Type-I Beta Subunit Synonyms

Protein Geranylgeranyltransferase Type I Beta Subunit, BGGI, GGTI, GGTase-I-Beta, Geranylgeranyl Transferase Type I Beta Subunit, PGGT1B, Type I Protein Geranyl-Geranyltransferase Beta Subunit

Protein Geranylgeranyltransferase Type-I Beta Subunit

Protein Geranylgeranyltransferase Type-I Beta Subunit Definition

Protein Geranylgeranyltransferase Type-I Beta Subunit Synonyms

Terms in Protein Geranylgeranyltransferase Type-I Beta Subunit category