Protein Kinase-A C-Alpha
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Protein Kinase-A -> Protein Kinase-A C-Alpha
Protein Kinase-A C-Alpha Definition
Expressed as 2 alternative isoforms (sperm-specific Isoform 2) by human PRKACA Gene (cAMP Ser/Thr Protein Kinase Family), Protein Kinase A C-Alpha is a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme Protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)
Protein Kinase-A C-Alpha Synonyms
Protein Kinase A C-Alpha, PKA C-Alpha, PRKACA, cAMP-Dependent Protein Kinase Alpha, cAMP-Dependent Protein Kinase Alpha-Catalytic Subunit
Terms in Protein Kinase-A C-Alpha category
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