Cancer Terms

Pyk2 and Map Kinase Pathway

Cancer Terms -> Biochemical Pathway -> Other Biochemical Pathway -> Pyk2 and Map Kinase Pathway

Pyk2 and Map Kinase Pathway Definition

This pathway is a compilation of Pyk2 effort cascades; in specific cell types the receptor and effectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatives the JNK cascade, starting with PAK followed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2. (BioCarta)

Pyk2 and Map Kinase Pathway Synonyms

Pyk2 and Map Kinase Pathway, Links between Pyk2 and Map Kinases

Terms in Pyk2 and Map Kinase Pathway category

Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods

No reproduction or republication permitted.