RAN GTPase Activating Protein-1
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RAN GTPase Activating Protein-1 Definition
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. (LocusLink)
RAN GTPase Activating Protein-1 Synonyms
RAN GTPase Activating Protein 1, FUG1, MGC20266, RANGAP1
Terms in RAN GTPase Activating Protein-1 category
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