RAS Family Oncogene

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RAS Family Oncogene Definition

Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein. Critically involved in cell activation and replication in many cell types, and disruption of its regulation can lead to uncontrolled growth.

RAS Family Oncogene Synonyms

RAS Family Oncogene, Oncogene RAS, RAS, RAS Oncogene, Retrovirus Associated Sequence Oncogene

Terms in RAS Family Oncogene category

Oncogene H-Ras
Oncogene K-Ras
Oncogene N-RAS