RET-H4 Oncogene
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RET-H4 Oncogene Definition
The PTC1 chimeric oncogene (RET/PTC1, RET/H4) is generated by fusion of the RET proto-oncogene receptor tyrosine kinase domain to the 5-prime terminal region of the H4 gene containing a putative leucine zipper. H4 shows no significant homology to known genes and the protein function is unknown. The RET receptor ligand is Glial Cell Line-Derived Neurotrophic Factor. The putative H4 leucine zipper mediates dimerization of the PTC1 oncoprotein, essential for PTC1 transforming activity. (NCI)
RET-H4 Oncogene Synonyms
RET/H4 Oncogene, RET/D10S170 Oncogene, RET/PTC1 Oncogene, TST1 Oncogene, Transforming Sequence, Thyroid 1
Terms in RET-H4 Oncogene category
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