RET-H4 Oncoprotein
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Oncoprotein -> RET-H4 Oncoprotein
RET-H4 Oncoprotein Definition
The PTC1 chimeric oncogene (RET/PTC1) is generated by fusion of the RET proto-oncogene receptor tyrosine kinase domain to the 5-prime terminal region of the H4 gene containing a putative leucine zipper. H4 shows no significant homology to known genes and the protein function is unknown. The RET receptor ligand is Glial Cell Line-Derived Neurotrophic Factor. The putative H4 leucine zipper mediates dimerization of the PTC1 oncoprotein, essential for PTC1 transforming activity. (from OMIM 601985 and NCI)
RET-H4 Oncoprotein Synonyms
RET/H4 Oncoprotein, RET/H4 Chimeric Oncoprotein
Terms in RET-H4 Oncoprotein category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.