Receptor-Interacting Serine-Threonine Protein Kinase-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Receptor-Interacting Serine-Threonine Protein Kinase-3

Receptor-Interacting Serine-Threonine Protein Kinase-3 Definition

Expressed in heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, lung, peripheral blood leukocytes, prostate, testis, and colon by human RIPK3 Gene (Ser/Thr Kinase Family), autophosphorylated (Lys50) cytoplasmic 518-aa 57-kDa Receptor-Interacting Serine/Threonine Kinase 3 contains a distinct C terminus that interacts with RIPK1and an N-terminal kinase domain similar to RIPK1 and RIPK2. RIPK3 also colocalizes in the mitochondrion with RIPK1. RIPK3 is recruited to the TNFR1 complex in a RIPK1-dependent manner and interacts with TRAF2. The RIPK3 C terminus is required to induce apoptosis through the activation of some or all caspases and also appears to activate NFKB. RIPK3 can stimulate NFKB nuclear translocation. (NCI)

Receptor-Interacting Serine-Threonine Protein Kinase-3 Synonyms

Receptor-Interacting Serine/Threonine Protein Kinase 3, RIP-Like Protein Kinase 3, RIP3, RIPK3, Receptor-Interacting Protein 3

Terms in Receptor-Interacting Serine-Threonine Protein Kinase-3 category

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