Rhodacyanine
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Rhodacyanine Definition
A synthetic heterocyclic pyridinium compound. MKT-077 is a water soluble lipophilic cationic molecule and an analog of rhodacyanine dye, which partitions into tumor cell mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest and apoptosis. This agent also shows selective cytotoxicity to cancer cells mediated by its binding to the hsp70 family protein mot-2 and reactivation of tumor suppressor p53 function.
Rhodacyanine Synonyms
Rhodacyanine Analog MKT-077, 1-Ethyl-2-[[-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]pyridinium Chloride, 1-ethyl-2-[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)-4-oxothiazolidin-2-ylidenemethyl] pyridinium chloride, FJ 776, MKT-077
Terms in Rhodacyanine category
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