SC-48334
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SC-48334 Definition
A synthetic, N-alkylated imino analogue of D-glucose. Miglustat competitively and reversibly binds to and inhibits the activity of UDP-glucose ceramide glucosyltransferase, which catalyzes the initial step in the synthesis of glycosphingolipids (GSL). This leads to a decrease in the production of glycosphingolipid, which has important roles in various cellular processes. Miglustat can be used in substrate reduction therapy in diseases in which the enzyme glucocerebrosidase, that is responsible for the breakdown of GSL, is deficient.
SC-48334 Synonyms
Miglustat, 1,5-(butylimino)-1,5-dideoxy-D-glucitol, 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-,(2R-(2alpha,3beta,4alpha,5beta))-, MIGLUSTAT, N-Butyl Deoxynojirimycin, N-Butylmoranoline, SC 48334, SC-48334, Zavesca
Terms in SC-48334 category
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