SGN-40
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Monoclonal Antibody -> SGN-40
SGN-40 Definition
A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic leukemia.
SGN-40 Synonyms
Dacetuzumab, Anti-huCD40 mAb, Monoclonal Antibody SGN-40, SGN-40, huS2C6
Terms in SGN-40 category
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