SKI Oncoprotein
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SKI Oncoprotein Definition
The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN. SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB. The effects of SKI can be overcome by increased expression of SMAD3. (from OMIM 164780 and NCI)
SKI Oncoprotein Synonyms
SKI Oncoprotein, SK Oncogene
Terms in SKI Oncoprotein category
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