SMAD7 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> SMAD7 Protein

SMAD7 Protein Definition

Encoded by MADH7 Gene (SMAD Family) and induced by TGF-beta and IFNG, ubiquitous (lung, vascular endothelium highest) 426-amino acid SMAD7 Protein is an inhibitory Activin/TGFBR1 signaling component containing DWA/MH1 and DWB/MH2 domains. SMAD7 lacks C-terminal phosphorylation sites of other MAD proteins, suggesting distinct regulation. Adaptor SMAD7 constitutively recruits nuclear E3 ubiquitin ligase SMURF2 to TGFBR complexes preventing SMAD2 access and causing proteasomal and lysosomal receptor degradation. SMAD7-expressing cells are susceptible to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion. SMAD7 decreases NFKB activity, promoting apoptosis. RAS suppresses SMAD7 inhibition of NFKB and potentiation of apoptosis. MADH7 and MADH6 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)

SMAD7 Protein Synonyms

SMAD7 Protein, MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 7 Protein, MADH7, Mothers Against DPP Homolog 7 Protein, Mothers Against Decapentaplegic Homolog 7 Protein, Mothers Against Decapentaplegic, Drosophila, Homolog 7 Protein, SMA- and MAD-Related Protein 7, hSMAD7

SMAD7 Protein

SMAD7 Protein Definition

SMAD7 Protein Synonyms

Terms in SMAD7 Protein category