Sodium Butyrate
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Sodium Butyrate Definition
The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.
Sodium Butyrate Synonyms
Sodium Butyrate, Butyrate, Butyrate sodium, Butyric Acid, Sodium Salt, Sodium butanoate, Sodium butyrate, butyric acid, sodium salt, sodium butanoate
Terms in Sodium Butyrate category
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