Suppressor of Cytokine Signaling Family Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Suppressor of Cytokine Signaling Family Protein

Suppressor of Cytokine Signaling Family Protein Definition

Encoded by Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes, Suppressor of Cytokine Signaling Family Proteins are cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Containing SH2 and SOCS BOX domains, SOCS proteins are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI)

Suppressor of Cytokine Signaling Family Protein Synonyms

Suppressor of Cytokine Signaling Family Protein, CIS Family Protein, Cytokine-Induced STAT Inhibitor Family Protein, SOCS Family Protein, SSI Family Protein, STAT-Induced STAT Inhibitor Family Protein

Terms in Suppressor of Cytokine Signaling Family Protein category

Cytokine Inducible SH2-Containing Protein