TAS-106
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TAS-106 Definition
A synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. 3'-C-ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation, and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule.
TAS-106 Synonyms
3'-C-ethynylcytidine, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, 3'-C-Ethynylcytidine, ECdy, ECyd, TAS-106
Terms in TAS-106 category
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