TLR8 Agonist VTX-2337
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Biological Response Modifier ->
Immunostimulant -> TLR8 Agonist VTX-2337
TLR8 Agonist VTX-2337 Definition
A small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities. TLR8 agonist VTX-2337 binds to TLR8, present in cutaneous dendritic cells, monocytes/macrophages, and mast cells, which may result in the activation of the central transcription factor nuclear factor-B, the secretion of proinflammatory cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response. Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in the innate immune system.
TLR8 Agonist VTX-2337 Synonyms
TLR8 Agonist VTX-2337, Toll-like Receptor 8 Agonist VTX-2337, VTX-2337
Terms in TLR8 Agonist VTX-2337 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.