Cancer Terms

TNF Receptor Family Gene

Cancer Terms -> Gene -> Ligand Binding Protein Gene -> Receptor Gene -> Cytokine Receptor Gene -> TNF Receptor Family Gene

TNF Receptor Family Gene Definition

Human TNF Receptor Family Genes encode transmembrane receptor proteins regulated by TNF Family ligands. TNF receptors typically contain intracellular death domains involved in the formation of a signal transducing death-inducing complex that includes FADD and caspases that trigger an apoptotic caspase cascade. Some TNF receptors can activate NF-Kappa-B, MAPK3/ERK1, MAPK8/JNK, BIRC1, BIRC2, BAG4/SODD, TRADD, or TRAF2 and transduce inflammation or anti-apoptotic proliferating signals. Some TNF Family Receptors act as competitive decoy receptors in bone resorption or suppress FasL- and LIGHT-mediated cell death. (NCI)

TNF Receptor Family Gene Synonyms

TNF Receptor Family Gene

Terms in TNF Receptor Family Gene category

TNFRSF10A Gene
TNFRSF10B Gene
TNFRSF11B Gene
TNFRSF1A Gene
TNFRSF1B Gene
TNFRSF5 Gene
TNFRSF6B Gene
TNFRSF6 Gene
TNFRSF8 Gene



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