TPMT V5 Allele
Cancer Terms ->
Gene ->
Enzyme Gene ->
Transferase Gene ->
Methyltransferase Gene ->
TPMT Gene -> TPMT V5 Allele
TPMT V5 Allele Definition
TPMT*V5 Allele is a variant form of 34-kb 10-exon human TPMT Gene (TPMT Family), which encodes polymorphic monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. Inhibited by S-adenosyl-L-homocysteine, TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine. TPMT contains a variable number of 17/18 bp tandem repeats (VNTR), from 3-9 (*V3-*V9), within the GC-rich 5'-flanking TPMT promoter region that modulate the level of TPMT enzyme activity (to a smaller extent than ORF-based SNP effects). A decrease in gene expression is seen with increasing repeat numbers. TPMT*V5 contains 5 VNTR. TPMT activity is thought to be an important determinant of toxicity associated with thiopurine medications.
TPMT V5 Allele Synonyms
TPMT*V5 Allele, TPMT-V5
Terms in TPMT V5 Allele category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.