Cancer Terms

Tacrolimus Analogue AP1903

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Response Modifier -> Tacrolimus Analogue AP1903

Tacrolimus Analogue AP1903 Definition

A lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. This agent is used to homodimerize the Fv-containing drug-binding domains of genetically engineered receptors such as the iCD40 receptor of the autologous dendritic cell vaccine BP-GMAX-CD1, resulting in receptor activation.

Tacrolimus Analogue AP1903 Synonyms

Dimerizer AP1903, AP1903

Terms in Tacrolimus Analogue AP1903 category



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