Tocainide Hydrochloride
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Agent Affecting Cardiovascular System ->
Antiarrhythmic Agent -> Tocainide Hydrochloride
Tocainide Hydrochloride Definition
The hydrochloride salt form of tocainide, a primary amine analog of lidocaine exhibiting class 1b antiarrhythmic property. Tocainide hydrochloride stabilizes the neuronal membrane by reversibly binding to and blocking open and inactivated voltage-gated sodium channels. This inhibits the inward sodium current required for the initiation and conduction of impulses and reduces the excitability of myocardial cells. This agent reduces the rate of rise and amplitude, and shortens the action-potential duration (APD) in both the Purkinje and muscle fibers. Tocainide also shortens the effective refractory period (ERP) of Purkinje fibers resulting in an increased the ERP/APD ratio. Overall these effects lead to the slowing of nerve impulses and stabilization of the heartbeat.
Tocainide Hydrochloride Synonyms
Tocainide Hydrochloride, Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, Monohydrochloride, TOCAINIDE HYDROCHLORIDE, Taquidil, Tonocard, Xylotocan
Terms in Tocainide Hydrochloride category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.