Cancer Terms

Tolazamide

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Digestive System Or Metabolism -> Anti-diabetic Agent -> Tolazamide

Tolazamide Definition

A sulfonylurea derivative and an antidiabetic agent with hypoglycemic property. Tolazamide binds to the ATP-dependent potassium channels on the plasma membrane of pancreatic beta-cells, which results in an inhibition of potassium efflux and membrane depolarization. Membrane depolarization stimulates calcium influx through voltage-gated calcium channels and subsequently induces the release of insulin from viable beta-cells thereby leading to a decrease in blood glucose levels. In addition, this agent potentiates the anti-diuretic effect of antidiuretic hormone (ADH).

Tolazamide Synonyms

Tolazamide, TOLAZAMIDE

Terms in Tolazamide category



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