Topoisomerase-IV Inhibitor
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Topoisomerase-IV Inhibitor Definition
A group of antibiotics that targets DNA topoisomerase IV. All quinolone derivatives belong to topo IV inhibitors. The other target of these substances is bacterial gyrase. Mutations in the quinolone resistance-determining region (QRDR) of subunits of both topo IV and gyrase confer resistance to single-step mutants.
Topoisomerase-IV Inhibitor Synonyms
Topoisomerase-IV Inhibitor
Terms in Topoisomerase-IV Inhibitor category
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