Transcriptional Co-Activator-CRSP33
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Transcriptional Co-Activator-CRSP33 Definition
Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP9 gene encodes this 33-kD protein that is subunit 9of the CRSP complex. The CRSP9 protein is required with the TAF(II)s for Sp1-mediated transcriptional activation. (from OMIM 605045, LocusLink 9443)
Transcriptional Co-Activator-CRSP33 Synonyms
Cofactor Required for Sp1 Transcriptional Activation Subunit 9, CRSP9
Terms in Transcriptional Co-Activator-CRSP33 category
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