Transcriptional Co-Activator-CRSP70
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Transcriptional Co-Activator-CRSP70 Definition
Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP6 gene at 11q14 encodes this 80-kD protein that is subunit 6 of the CRSP complex. This CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s.
Transcriptional Co-Activator-CRSP70 Synonyms
Cofactor Required for Sp1 Transcriptional Activation Subunit 7, CRSP7
Terms in Transcriptional Co-Activator-CRSP70 category
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