Translation Initiation Factor-EIF-2B Delta Subunit
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Translation Initiation Factor-EIF-2B Delta Subunit Definition
Encoded as 2 alternative isoforms by human EIF2B2 Gene (EIF2B Alpha/Beta/Delta Family), 523-aa 58-kDa Translation Initiation Factor EIF-2B Delta Subunit acts in EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. EIF2B4 defects cause VWM and ovarioleukodystrophy. (NCI)
Translation Initiation Factor-EIF-2B Delta Subunit Synonyms
Translation Initiation Factor EIF-2B Delta Subunit, EIF-2B, EIF-2B GDP-GTP Exchange Factor, EIF2B, EIF2B Delta, EIF2B4, Eukaryotic Translation Initiation Factor 2B Subunit 4 Delta 67-kDa
Terms in Translation Initiation Factor-EIF-2B Delta Subunit category
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