Translation Initiation Factor-EIF-2B Epsilon Subunit
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Translation Initiation Factor-EIF-2B Epsilon Subunit Definition
Encoded by human EIF2B5 Gene (EIF2B Gamma/Epsilon Family), 721-aa 80-kDa Translation Initiation Factor EIF-2B Epsilon Subunit acts in EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. The N-terminal region of eIF2B-epsilon contains a putative nucleotide-binding domain that may be directly involved in nucleotide exchange. EIF2B5 defects cause VWM, ovarioleukodystrophy, and CLE. (NCI)
Translation Initiation Factor-EIF-2B Epsilon Subunit Synonyms
Translation Initiation Factor EIF-2B Epsilon Subunit, EIF-2B, EIF-2B GDP-GTP Exchange Factor, EIF2B Epsilon, EIF2B5, Eukaryotic Translation Initiation Factor 2B Subunit 5 Epsilon 82-kDa
Terms in Translation Initiation Factor-EIF-2B Epsilon Subunit category
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