Tumor Protein p53-Binding Protein-2
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Tumor Protein p53-Binding Protein-2 Definition
Found only in the cytosol, TP53BP2 impedes cell cycle progression beyond G2/M. It enhances p53 trans-activation function and induces p21 (CDKN1A) expression. TP53BP2 contains ankyrin repeats and an SH3 domain, required for interaction with p53 and BCL2; TP53BP2 cannot bind both proteins simultaneously. (from OMIM 602143 and NCI)
Tumor Protein p53-Binding Protein-2 Synonyms
Tumor Protein p53 Binding Protein 2, BCL-2 Binding Protein, TP53BP2, p53-Binding Protein 2
Terms in Tumor Protein p53-Binding Protein-2 category
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