Tumor Susceptibility Gene-101 Protein
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Tumor Susceptibility Gene-101 Protein Definition
Encoded by human TSG101 Gene and expressed in heart, brain, placenta, lung, liver, kidney, and pancreas, 390-amino acid 44 kD cytoplasmic Tumor Susceptibility Gene 101 Protein appears important for genomic stability and cell cycle regulation. A negative growth or differentiation regulator through p21 association and ubiquitin-conjugating enzyme homolog, TSG101 protein may be negative ubiquitin regulator or act in protein-ubiquitin conjugate removal. Nuclear TSG101 protein interacts with DMAP1; the coiled-coil domain interacts with cytosolic phosphoprotein Stathmin. TSG101 functions in vacuolar protein sorting and viral budding. The ubiquitin enzyme-2 variant domain binds to ubiquitin and to the p6 domain PTAP motif of HIV-1 Gag protein. Mutations occur at high frequency in breast cancer during tumorigenesis or progression. (from Swiss-Prot, OMIM, and NCI)
Tumor Susceptibility Gene-101 Protein Synonyms
Tumor Susceptibility Gene 101 Protein, TSG101
Terms in Tumor Susceptibility Gene-101 Protein category
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