UNC-13 Homolog-B Protein
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UNC-13 Homolog-B Protein Definition
Encoded by human UNC13 Gene, 1591-aa UNC-13 Homolog B contains 3 C2 domains, a C1 DAG-binding domain, and highly conserved N- and C-terminal similarity to rat Munc13 homologues. UNC13 is a putative DAG receptor and may act in a PKC-independent DAG-activated apoptosis pathway. UNC13 also appears to be a presynaptic protein that promotes synaptic vesicle priming by acting through syntaxin. Post-docking synaptic vesicle exocytosis priming requires SNARE complex formation. The default closed syntaxin configuration is incompatible with SNARE formation; the N-terminus binds the SNARE motif and occludes SNARE protein interactions. UNC13 binding to the syntaxin N-terminus may promote an open syntaxin configuration and prime synaptic vesicles for fusion. (NCI)
UNC-13 Homolog-B Protein Synonyms
UNC-13 Homolog B, Munc13 Homolog, UNC-13-Like, UNC13
Terms in UNC-13 Homolog-B Protein category
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