Upstream Stimulatory Factor 1
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Upstream Stimulatory Factor 1 Definition
Ubiquitously expressed by human USF1 Gene, 310-aa 34-kDa nuclear Upstream Stimulatory Factor 1 is a bHLH transcription factor that binds to symmetrical E-box DNA (CACGTG) in viral and cellular promoters as a homodimer or USF1/USF2 heterodimer (USF). Efficient DNA binding requires dimerization with another bHLH protein and USF1 can act synergistically with GTF2I to activate transcription. Direct GTF2I interaction requires the USF1 activation and dimerization domains. USF1/USF2A heterodimer represents most USF binding activity. (NCI)
Upstream Stimulatory Factor 1 Synonyms
Upstream Stimulatory Factor 1, Major Late Transcription Factor 1, USF1
Terms in Upstream Stimulatory Factor 1 category
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