Cancer Terms

WFDC1 Protein

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WFDC1 Protein Definition

Encoded by human WFDC1 Gene, the 220-amino acid 24 kD (precursor) secretory Prostate Stromal Protein ps20 (WAP Family) is a growth inhibitor that contains a WAP four-disulfide core domain characteristic of protease inhibitors. The WAP signature motif contains eight cysteines forming four disulfide bonds at the core of proteins that functions as a protease inhibitor in many family members. Human ps20 shares approximately 86% and 88% identity with the rat and mouse secreted growth inhibitor proteins. Loss of ps20 is associated with prostate, breast, and hepatocellular cancers and Wilms' tumor. (from SWISS-PROT, OMIM, Proteome, and NCI)

WFDC1 Protein Synonyms

WFDC1 Protein, Prostate Stromal Protein ps20, WAP Four-Disulfide Core Domain 1 Protein, WFDC1

Terms in WFDC1 Protein category



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