Cancer Terms

WHSC1 wt Allele

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WHSC1 wt Allele Definition

Human WHSC1 wild-type allele is located in the vicinity of 4p16.3 and is approximately 111 kb in length. This allele, which encodes putative WHSC1 protein, plays a role in the induction of protein ubiquitination. A frequently detected t(4;14)(p16.3;q32) translocation in multiple myeloma results in dysregulation of the WHSC1 gene, resulting in the promotion of oncogenic transformation.

WHSC1 wt Allele Synonyms

WHSC1 wt Allele, MMSET Gene, NSD2 Gene, TRX5 Gene, Wolf-Hirschhorn Syndrome Candidate 1 wt Allele

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