Zosuquidar Trihydrochloride
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Zosuquidar Trihydrochloride Definition
A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. (NCI04)
Zosuquidar Trihydrochloride Synonyms
Zosuquidar Trihydrochloride, (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, Trihydrochloride, LY335979, ZOSUQUIDAR TRIHYDROCHLORIDE, zosuquidar trihydrochloride
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