Dimesna
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Dimesna Definition
A synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.
Dimesna Synonyms
Dimesna, 2,2'-Dithio-bis-ethanesulfonate, Disodium Salt, 2,2'-Dithiobisethanesulfonic Acid, Disodium Salt, BNP7787, Mesna Disulfide, Tavocept, dimesna
Terms in Dimesna category
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