Mixed-Backbone Oligonucleotide

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Agent -> Antisense Agent -> Mixed-Backbone Oligonucleotide

Mixed-Backbone Oligonucleotide Definition

Second generation of antisense agents with segments of modified phosphorothioate oligonucleotides. The most extensively studied and used agents contain 2'-substituted modifications, such as 2'-O-methyl. In animal models, such modifications were associated with improved in vivo stability, oral bioavailability, and markedly decreased concentration-related adverse events that were common for the first generation of oligonucleotides and have been attributed to sequence-independent and sequence-specific effects. (NCI)

Mixed-Backbone Oligonucleotide Synonyms

Mixed-Backbone Oligonucleotide, MBO, Mixed-Backbone Oligonucleotides

Terms in Mixed-Backbone Oligonucleotide category

GEM 132
GEM 231
GEM 91
GEM 92