Therapeutic Transforming Growth Factor-Beta

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Agent -> Therapeutic Growth Factor -> Therapeutic Transforming Growth Factor -> Therapeutic Transforming Growth Factor-Beta

Therapeutic Transforming Growth Factor-Beta Definition

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta (TGF-beta) with proapoptotic and antineoplastic properties. TGF-beta may suppress tumor cell growth by decreasing the expression of cyclin D1, a cell cycle regulatory protein, and downregulating the expression of the oncogene c-myc. This agent is also involved in T cell-mediated immunosuppression by CD4+CD25+ T cells, which permits cancer cells to evade immune surveillance. (NCI04)

Therapeutic Transforming Growth Factor-Beta Synonyms

Recombinant Transforming Growth Factor-Beta, Bone-Derived Transforming Growth Factor, TGF-Beta, Therapeutic Milk Growth Factor, Therapeutic TGF B, Therapeutic TGF-Beta, rTGF-Beta

Terms in Therapeutic Transforming Growth Factor-Beta category

Therapeutic Transforming Growth Factor-Beta 1
Therapeutic Transforming Growth Factor-Beta 2
Therapeutic Transforming Growth Factor-Beta 3